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Experts believe that Anastasia's underboss Carlo Gambino helped orchestrate the hit to take over the family.
Lupo was partner in many ventures with Morello, who was the original capo di tutti capi (boss of bosses), a title that would later be coveted by D'Aquila.
The group's operations extend from New York and the eastern seaboard to California.
Its illicit activities include labor and construction racketeering, gambling, loansharking, extortion, money laundering, prostitution,, and fencing.
When he and his partner by business and marriage, Giuseppe Morello, were sent to prison for counterfeiting in 1910, Salvatore "Toto" D'Aquila, one of Lupo's chief captains, took over.
D'Aquila was an influential emigrant from Palermo who joined the Lupo gang based in East Harlem.